Methyl iodide → HCID 11247989, compound

Participants

Reaction Steps

400 mg (0.91 mmol) of the compound obtained in example 1 was dissolved in 5 ml of DMF, then 250 mg (1.82 mmol) of K2CO3 and 170 mg (1.18 mmol) of CH3I were added thereto. The reaction was stirred at room temperature for 12 hours, 30 ml of saturated NaHCO3 solution was added, and aqueous layer was extracted with 50 ml of ethyl acetate. Organic layer was washed with brine and dried over anhydrous MgSO4, concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=1:1), to give 390 mg (yield: 95%) of the target compound.

Provenance & Evidence