Acetic Anhydride → HCID 178499576, compound

Participants

Reaction Steps

88 mg (0.21 mmol) of the compound obtained in example 5 was dissolved in methylenechloride, then 61 μl (0.64 mmol) of acetic anhydride, 120 μl (0.86 mmol) of triethylamine and 8 mg (0.06 mmol) of 4-dimethylaminopyridine were added thereto. The reaction was stirred at room temperature for 12 hours, saturated NaHCO3 solution was added, aqueous layer was extracted with methylenechloride. Organic layer was washed with brine and dried over anhydrous MgSO4, concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=1:2), to give 35 mg (yield: 34%) of the target compound.

Provenance & Evidence