HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 6-Pyridin-2-yl-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 3-oxo-6-(pyridin-2-yl)-2,3-dihydropyridazine-4-carboxylate | HCID 20527880 | — |
| Reactant | 6-[4-(Benzyloxy)phenyl]-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid | HCID 69218872 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 6-Pyridin-2-yl-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid | HCID 69217260 | 96.2% |
Reaction Steps
Working as in example 19 for the preparation of 6-[4-(benzyloxy)phenyl]-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid, but starting with 4 g of ethyl 6-pyridin-2-yl-3-oxo-2,3-dihydropyridazine-4-carboxylate, 49 cm3 of one molar sodium hydroxide solution and 50 cm3 of one molar hydrochloric acid solution, 3.44 g of 6-pyridin-2-yl-3-oxo-2,3,4,5-tetrahydropyridazine-4-carboxylic acid were obtained in the form of a beige-colored solid melting at a temperature above 260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07309701B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-93e50be1402f42158190ee920cc8105d |
| Source note | uspto-grants-2007_12 |