Triphenylphosphine → (4-Carboxybenzyl)triphenylphosphonium bromide

Participants

Reaction Conditions

Reaction Steps

10.7 g (50 mmole) of α-bromo-4-toluoic acid and 13.1 g (50 mmole) of triphenylphosphine were dissolved in 105 ml of toluene under a nitrogen atmosphere. The mixture was heated at 115° C. for 5 hours. After cooling, the mixture was filtered and dried in a vacuum-oven at 60° C. and 22.6 g of a white solid were obtained (yield 94.5%).

Provenance & Evidence