Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | HCID 69511759 | HCID 69511759 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 69512330 | HCID 69512330 | 66% |
Reaction Steps
A mixture of 9.1 g of 3-(R)-(tetrahydropyran-2-yloxy)-hexahydro-furo[3,2-b]furan-6-(S)-yl 4-(tetrahydropyran-2-yloxy)cinnamate (25), 0.48 g of pyridinium 4-toluenesulfonate and 60 ml of absolute ethanol was heated at 60° C. for 3 hours under a nitrogen atmosphere. A clear solution was obtained which was added dropwise to 50 g of ice and 100 g of water with vigorous stirring. A white solid precipitated. It was filtered off, washed with water and dried in a dessicator over silica. 3.7 g of a white powder was obtained (yield: 66%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07311948B2 |
|---|
| Source dataset | uspto-grants-2007_12 |
|---|
| ORD ID | ord-515ef93cb5d74b3eae5f870180c9f7ed |
|---|
| Source note | uspto-grants-2007_12 |
|---|
