Triethylamine → HCID 69510007, compound

Participants

Reaction Steps

3.3 g of 4-(6-acryloyloxyhexyloxy)benzoyl chloride dissolved in 40 ml of dichloromethane was added dropwise to a solution of 2.4 ml of triethylamine, 0.3 g of 4-N,N′-dimethylaminopyridine and 1.8 g of 3-(R)-hydroxy-hexahydro-furo[3,2-b]furan-6-(S)-yl 4-hydroxycinnamate (26) in 40 ml of dichloromethane. The reaction was stirred overnight at room temperature. The solution was extracted with 80 ml of 2.5 N HCl. The organic layer was washed with water, dried over MgSO4 and passed through a silica pad. The solvent was evaporated. The crude producty was recrystallised twice from ethyl acetate. 2.8 g of white crystals were obtained (yield: 61%). The melting point of the compound was 142° C.

Provenance & Evidence