Water → HCID 86600671, compound

Participants

Reaction Steps

A mixture of 0.63 g (2.4 mmol) of 6-methyl-4-(4-trifluoromethyl-1H-1-pyrazolyl)-2-chloropyrimidine, 0.39 g (2.4 mmol) of 4-hydroxy-2-trifluoromethylpyridine and 0.66 g (4.8 mmol) of K2CO3 in 20 ml of acetonitrile stirred under reflux for 8 h and then allowed to stand at RT overnight. The mixture is poured into 40 ml of water and extracted four times with in each case 20 ml of CH2Cl2. The combined organic phases are dried over Na2SO4 and concentrated. Chromatographic purification on silica gel using heptane/ethyl acetate (7:3) gives 0.8 g (85%) of 6-methyl-4-(4-trifluoromethyl-1H-1-pyrazolyl)-2-(2-trifluoromethylpyridin-4-yloxy)pyrimidine.

Provenance & Evidence