Diethyl Ether → HCID 20591842, compound

HRID 970282Notes

Reaction equation

[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH3:8][CH:9]([CH2:18][CH2:19][CH:20]=[C:21]([CH3:23])[CH3:22])[CH2:10][CH:11]([OH:17])[CH:12]([N+:14]([O-:16])=[O:15])[CH3:13].CCOCC>OS(O)(=O)=O.O>[C:1]([O:17][CH:11]([CH2:10][CH:9]([CH3:8])[CH2:18][CH2:19][CH:20]=[C:21]([CH3:23])[CH3:22])[CH:12]([N+:14]([O-:16])=[O:15])[CH3:13])(=[O:3])[CH3:2]

Participants

Conditions

Temperature: -10 °C

Procedure

A flask containing 1.3 g of acetic anhydride was cooled to −10° C. with a salt-ice bath, and 2.34 g of 6 was added with magnetic stirring under an N2 atmosphere. After 10-15 min, 2-5 drops of concentrated H2SO4 were added. The reaction mixture was allowed to stir for an additional 10 min, after which it was treated with 40 mL of ether and 10 mL of H2O. The mixture was extracted three times with 15 mL of saturated aqueous sodium bicarbonate and once with 10 mL of saturated aqueous NaCl. The ether layer was dried over anhydrous MgSO4, and the solvent was removed by rotary evaporation to yield 2.41 g (88%) of a mixture of stereoisomers of the nitro acetate 7. 1H NMR δ (ppm) 5.4 (broad m, CH2CH(OAc)), 5.2 (t, C═CH), 4.65 (m, CH3CHNO2), 2.1 (s, CH3CO2), 2.0 (br m, ═CHCH2), 1.60 and 1.65 (both s, CH3C(CH3)═), 1.5 (d, CH3CHNO2), 1.2-1.5 (m, CH2CH(CH3)CH2), 0.95 (d, CH2CH(CH3)CH2).

Workup

stirringto stir for an additional 10 min
extractionThe mixture was extracted three times with 15 mL of saturated aqueous sodium bicarbonate
dry with materialThe ether layer was dried over anhydrous MgSO4
customthe solvent was removed by rotary evaporation

Sources & evidence

ORD record: ord-470996a8d4284e8cb89ed8b3daa0e8dc
Source dataset: uspto-grants-2007_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07312191B2

Reaction notes

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