Tetrahydrofuran → HCID 86591422, compound

Participants

Reaction Steps

A one dram vial was charged with compound 145A (13 mg, 0.033 mmol), THF (0.5 mL) and TBAF (33 L, 0.033 mmol) under argon. The reaction mixture was stirred at RT for 20 min., and then diluted with EtOAc (10 mL), washed with sat. NaHCO3 (10 mL), water (10 mL) and brine (10 mL). The organic layer was dried over MgSO4 and concentrated in vacuo to give 145B as a yellow solid (12 mg). HPLC retention time=2.74 min. (Condition A), M+=319.

Provenance & Evidence