Dimethyl 2-amino-5-fluoroterephthalate → 6-Ethylpyridine-3-carbonitrile

HRID 970333Notes

Reaction equation

HRID 970333 reaction equation
[CH:1]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][N:4]=1)=[CH2:2].COC(=O)C1C=C(F)C(C(OC)=O)=CC=1N>>[CH2:1]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][N:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 16748146Dimethyl 2-amino-5-fluoroterephthalateHCID 190453106-Ethenylpyridine-3-carbonitrile

Product 1

HCID 181776766-Ethylpyridine-3-carbonitrile

Procedure

Compound 384B was prepared from 384A by a route analogous to that described for the preparation of compound 174B. HPLC retention time=1.24 min. (Condition A), M+=133.

Sources & evidence

ORD record
ord-288d317497a3478498f71b78e6569336
Source dataset
uspto-grants-2007_12
Patent number
US07312209B2

Reaction notes

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