Nitric Acid → N-(4-Imidazol-1-yl-2-methyl-6-nitro-phenyl)-acetamide

Participants

Reaction Steps

To a solution of 4-imidazol-1-yl-2-methyl-phenylamine (1 g, 5.78 mmol) in CH2Cl2 (20 mL) was added Ac2O (0.7 mL, 7.28 mmol) at 0° C. The reaction mixture was stirred at room temperature for 14 h and diluted with water. The aqueous layer was extracted with CH2Cl2 and the combined organic layers were washed with saturated NaHCO3 and brine, dried over Na2SO4, and concentrated in vacuo to give a white solid. The white solid was suspended in H2SO4 (conc.) (15 μL). Then HNO3 (conc.) (0.312 mL) was added to the suspension at 0° C. The reaction mixture was slowly warmed to room temperature and stirred at room temperature for 4 h. After cooling to −10° C., the reaction mixture was neutralized with ammonium hydroxide extracted with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated. The residue was purified by flash chromatography (1:9:5 MeOH/THF/hexane) to yield the title compound (0.61 g, 41%). 1H NMR (300 MHz, CD3OD) δ 8.11 (1H, s), 7.45-7.56 (2H, m), 7.38 (1H, dd, J=2.4, 8.4 Hz), 7.14 (1H, s), 2.33 (3H, s), 2.18 (3H, s).

Provenance & Evidence