p-Toluenesulfonic acid → HCID 68566087, compound

Participants

Reaction Steps

To solution of (trifluoromethyl)acetaldehyde ethyl hemiacetal (1.2 equiv.) in toluene is added (R)-(+)-α-methylbenzylamine (1 equiv.) and catalytic amount of p-toluenesulfonic acid. The solution is heated at reflux under a Dean-Stark apparatus. After 3 hr, the reaction flask is fitted with a short-path condenser and the reaction contents were fractionally distilled to give the title compound as a colorless oil.

Provenance & Evidence