Trifluoroacetic acid → HCID 68565462, compound

Participants

Reaction Steps

{(2S,4S)-[(R)-hydroxy-(6-methoxy-[1,5]naphthyridin-4-yl)ethyl]-2-(trifluoromethyl)piperidin-4-yl}carbamic acid tert-butyl ester (1j) is dissolved in CH2Cl2 and TFA (1:1, v/v). After 2 hrs, the solution is concentrated to dryness under vacuum and the residue is redissolved in 4 M HCl in dioxane. After 30 min, the slurry is triturated with Et2O and filtered. The solid is dissolved in H2O and the solution is made basic with aqueous NaOH. The basic aqueous solution is concentrated to dryness under vacuum and the residue is dried under high vacuum. The resulting solid is extracted with CH2Cl2/MeOH (10:1, v/v), and the combined extracts are concentrated and dried under high vacuum to give the title compound.

Provenance & Evidence