Chlorotrimethylsilane → tert-Butyl 4-((trimethylsilyl)oxy)-5,6-dihydropyridine-1(2H)-carboxylate

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (1 equiv.) in DMF is added TMSCl (1.5 equiv.) and triethylamine (1.5 equiv.) and the reaction solution is heated at 80° C. After 3 hrs the reaction is allowed to cool to RT and the DMF is removed in vacuo. The remaining residue is dissolved in CH2Cl2 and the solution is washed with 10% NaHCO3, dried over Na2SO4, and concentrated to afford the crude title compound. This is used without further purification.

Provenance & Evidence