HCID 21054729, compound → 1-Boc-4-aMino-4-trifluoroMethylpiperidine

HRID 970374Notes

Reaction equation

HRID 970374 reaction equation
C(OC([NH:11][C:12]1([C:25]([F:28])([F:27])[F:26])[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:14][CH2:13]1)=O)C1C=CC=CC=1>[Pd].CCO>[NH2:11][C:12]1([C:25]([F:28])([F:26])[F:27])[CH2:13][CH2:14][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:22])[CH3:23])=[O:19])[CH2:16][CH2:17]1

Participants

4

Reactant 1

HCID 21054729HCID 21054729, compound

Product 1

HCID 210547281-Boc-4-aMino-4-trifluoroMethylpiperidine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10% Palladium on carbon (a catalytic amount) is added carefully to a solution of 4-(benzyloxycarbonyl)amino-1-(tert-butoxycarbonyl)-4-(trifluoromethyl)piperidine (3d) (1 equiv.) in EtOH, and the mixture is shaken under H2 (50 psi) on a Parr apparatus. When the reaction is complete, the solution is filtered through a pad of celite®, and the filter pad is washed with EtOH. The filtrate is concentrated to yield the title compound.

Workup

  1. filtrationthe solution is filtered through a pad of celite®
  2. washthe filter pad is washed with EtOH
  3. concentrationThe filtrate is concentrated

Sources & evidence

ORD record
ord-bc4b36888cab4c0e86042163707bc827
Source dataset
uspto-grants-2007_12
Patent number
US07312212B2

Reaction notes

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