Hydrochloric Acid → HCID 69180446, compound

Participants

Reaction Steps

7.1 448 g of NaH are introduced into 9 l of DMF, then 967 g of cyanoacetamide are added in portions over the course of 1 hour at 2-8° with strong ice cooling and under a nitrogen atmosphere. The mixture is stirred for a further 30 minutes, 600 ml of 1-fluoro-2-nitrobenzene are added, and the mixture is stirred for a further 2 hours. The mixture is poured into 50 l of ice-water, acidified using 3 l of conc. HCl and subjected to further conventional work-up, giving 956 g of 2-cyano-2-(2-nitrophenyl)acetamide (“GA”), m.p. 172-174°.

Provenance & Evidence