HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[(4-Fluorophenyl)methyl]piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(4-Fluoro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 22676679 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | 4-[(4-Fluorophenyl)methyl]piperidine hydrochloride | HCID 17039492 | — |
Reaction Steps
N-(t-butoxycarbonyl)-4-(4-fluorophenylmethyl)piperidine (11.2 g, 38.2 mmol) was dissolved in 4M HCl in dioxane (50 mL). The reaction was stirred for 15 min and then conc. in vacuo to a white solid. The solid was dissolved in 3% MeOH/CH2Cl2 in EtOAc/MeOH while warming once all solids were dissolved hexanes was added. The crystallization was allowed to cool to room temperature and then placed at 4° C. for 16 h. The white solids were filtered off to yield 8.4 g of product. MS (ESI) 194 (M−HCl+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07312222B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-62e93219c35e4a2dba44903b1a137026 |
| Source note | uspto-grants-2007_12 |