Ethyl Acetate → HCID 15540529, compound

Participants

Reaction Steps

(+/−)-N-(t-butoxycarbonyl)-2-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]methyl]-piperidine (340 mg, 0.87 mmol) was dissolved in 4M HCl in dioxane (10 mL). The reaction was stirred for 1 h and then conc. in vacuo to a white solid. The solid was partioned between 10% NaOH and EtOAc. The layers were separated and the aqueous layer was extracted with EtOAc. The organic layers were combined, dried over MgSO4, and conc. in vacuo to a white solid yielding 250 mg of product. MS (ESI) 291 (M+H).

Provenance & Evidence