HCID 19080978, compound → tert-Butyl 2-(hydroxymethyl)morpholine-4-carboxylate

HRID 970406Notes

Reaction equation

HRID 970406 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][O:15]CC2C=CC=CC=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>[Pd].CO>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][OH:15])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 19080978HCID 19080978, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 5201202tert-Butyl 2-(hydroxymethyl)morpholine-4-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a stirring solution of (+/−)-N-(t-butoxycarbonyl)-2-(phenylmethoxymethyl)-morpholine (595 mg, 1.94 mmol) and 20% palladium on carbon (120 mg, Aldrich) in MeOH (20 mL) was added 50 psi of hydrogen. The reaction was stirred for 4 h. The reaction was filtered and the filtrate was conc. in vacuo to a colorless oil. The oil can be used without further purification. MS (CI) 218 (M+H).

Workup

  1. filtrationThe reaction was filtered
  2. customThe oil can be used without further purification

Sources & evidence

ORD record
ord-505e419cb80f4976bc145aefe8734fe4
Source dataset
uspto-grants-2007_12
Patent number
US07312222B2

Reaction notes

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