Trifluoroacetic acid → HCID 17986359, compound

Participants

Reaction Steps

2.27 g (6.72 mmol) of [4-(3-nitro-benzoylamino)-butyl]-carbamic acid-tert-butyl ester is mixed with 9 ml of trifluoroacetic acid and stirred for 3 hours at room temperature. The batch is carefully added to 2N NaOH solution and then extracted from ethyl acetate. The combined organic phases are filtered through a Whatman filter and concentrated by evaporation. The crude product that is obtained is recrystallized from ethanol/diisopropyl ether. 519 mg (2.19 mmol, corresponding to 33% of theory) of the product is obtained.

Provenance & Evidence