反应详情

To a solution of 4-(1-piperazinyl)-6,7-dimethoxy quinazoline (200 mg, 0.73 mmol) and pyridine (0.5 mL, 6.4 mmol) in dichloromethane (20 mL) was added a solution of product 1d in dichloromethane (20 mL) and stirred overnight. Methanol was added for quenching excess thiophosgene, and the residue after removal of solvent was purified by silica gel column chromatography eluting with 5% methanol/dichloromethane and further recrystallized from dichloromethane/hexane to give 80 mg (20%).

1. customfor quenching excess thiophosgene
2. customthe residue after removal of solvent
3. customwas purified by silica gel column chromatography
4. washeluting with 5% methanol/dichloromethane
5. customfurther recrystallized from dichloromethane/hexane
6. customto give 80 mg (20%)