反应详情

To a solution of 4-piperazinopyrido[3′,2′;4,5]thieno[3,2-d] pyrimidine (200 mg, 0.74 mmol) and pyridine (0.5 mL, 7.9 mmol) in dichloromethane (20 mL) was added a solution of product 1d in dichloromethane (20 mL) and this was stirred overnight. Methanol was added to quench excess thiophosgene, and the residue after removal of solvent was purified by silica gel column chromatography eluting with 5% methanol/dichloromethane and further recrystallized from dichloromethane/hexane to give 60 mg (15%).

1. customto quench excess thiophosgene
2. customthe residue after removal of solvent
3. customwas purified by silica gel column chromatography
4. washeluting with 5% methanol/dichloromethane
5. customfurther recrystallized from dichloromethane/hexane
6. customto give 60 mg (15%)