HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 970536Generated: October 26, 2026
Ammonium Acetate → 4-Chloro-6-methyl-2-oxo-1,2-dihydro-quinoline-3-carbonitrile
https://huagongshe.com/reaction/970536
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 2,4-Dichloro-6-methylquinoline-3-carbonitrile | HCID 21081929 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-Chloro-6-methyl-2-oxo-1,2-dihydro-quinoline-3-carbonitrile | HCID 21081963 | 69% |
Reaction Steps
Ammonium acetate was added to a suspension of Compound 105 (7.1 g, 29.95 mmol) in glacial acetic acid and heated at 140° C. for 4 h. The solution was cooled and poured into ice water. The solids formed were filtered, washed by water, and dried under vacuum to yield 4.5 g (69%) of white solids. M.P. 264° C. 1H NMR (DMSO-d6): δ 2.32 (s, 3H), 7.34 (d, J=8.4 Hz, 1H), 7.63 (dd, J=1.5, 8.4 Hz, 1H), 7.75 (s, 1H). EIMS m/z 219 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07312220B2 |
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| Source dataset | uspto-grants-2007_12 |
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| ORD ID | ord-244910db77d7466e9a6445bf2b501cd8 |
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| Source note | uspto-grants-2007_12 |
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