HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-Hydroxyquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Oxo-4-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-1,2-dihydro-quinolin-3-carbonitrile | HCID 21081943 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Hydroxyquinoline | HCID 6038 | — |
Reaction Steps
A solution of Compound 116 (364 mg, 1 mmol) in DMF was added to a stirred suspension of NaH (60% in mineral oil, 44 mg, 1.1 mmol) in DMF at room temperature under argon atmosphere. The solution was stirred at room temperature for 1 h and the corresponding alkyl halide was added via syringe. The solution was further stirred at room temperature for 3 to 48 h (TLC control). The reaction was worked up as described in General Procedure C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07312220B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-e8651656437948a798fd3de6d062ed26 |
| Source note | uspto-grants-2007_12 |