Triphosgene → HCID 85823632, compound

Participants

Reaction Steps

To a solution of 5.0 g (27.58 mmol) of cyclopentylthiophen-2-ylmethylamine in 40 ml of methylene chloride at 10° C. was added slowly with stirring 4.09 g (13.79 mmol) of triphosgene in 35 ml of methylene chloride. The reaction was allowed to continue stirring at room temperature for 64 hours, refluxed for 4 hours and 25 hours more at room temperature. The solvent was evaporated and the residue extracted with n-hexane. The organic solution was concentrated to yield 4.96 g (20.34 mmol) of a brown oil (74%). 1H-NMR (CDCl3):δ 1,4 (m, 8H), 4,2 (bs, 1H), 4,5 (m, 2H), 6,8–7,3 (m, 3H).

Provenance & Evidence