Methanol → HCID 69421115, compound

Participants

Reaction Steps

To the product from step d (130 mg) in acetone (7 mL) was added Jones' reagent (1.0 mL) at 0° C. The mixture, while stirring, was allowed warm from 0° C. to rt. for 1 hr. Sodium bicarbonate and methanol were added, and the solvent was evaporated. The crude product was purified by reverse phase HPLC purification (acetonitrile/water 30% to 100% gradient) to provide (2S,3R)-5-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)-3-methylpentanoic acid as a clear oil. LC-MS found: (M+1)+=506.40.

Provenance & Evidence