(7-Nitro-2,3-dihydro-1,4-benzodioxin-2-yl)methanol → (7-Amino-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol

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Reaction Steps

(7-nitro-2,3-dihydro-benzo[1,4]dioxin-2-yl)-methanol (1.0 g, 4.7 mmol) was dissolved in methanol (30 ml) and palladium on activated carbon was added (0.10 g, 5% wt). The mixture was shaken on a parr shaker under H2(g) atmosphere (60 psi) for 24 hours. The mixture was filtered through celite and evaporated to give 722 mg of material as a white solid (86%), which was used as such for the next step. M/z=182 (m+1). Lc: 0.82 minutes.

Provenance & Evidence