HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 10702137, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Lithium aluminum hydride | HCID 28112 | — |
| Reactant | Ethyl 5-nitro-1H-indole-2-carboxylate | HCID 280312 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 10702137 | HCID 10702137 | 98% |
Reaction Steps
2-Ethoxycarbonyl-5-nitroindole (500 mg, 0.002 mol) was dissolved in 50 mL THF, added lithium tetrahydroaluminate (341 mg, 0.00898 mol) in 3 portions and stirred at room temperature overnight. Water (341 μL), 15% NaOH solution (341 μL), and water (1.1 mL) were added cautiously and the mixtured was filtered. The filtrate was concentrated under vacuum to give the product (300 mg, 98%) as an oil. m/z=162.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07312233B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-d78c55ea0d11435795945981c1d200bf |
| Source note | uspto-grants-2007_12 |