HCID 86587597, compound → HCID 86587596, compound

HRID 970686Notes

Reaction equation

HRID 970686 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:16]=[CH:15][C:14]([N:17]=[CH:18][N:19]3[CH2:24][CH2:23][CH:22]([C:25]([O:27]CC)=[O:26])[CH2:21][CH2:20]3)=[CH:13][CH:12]=2)=[O:10])=[C:4]([C:30](=[O:40])[NH:31][C:32]2[CH:37]=[CH:36][C:35]([C:38]#[CH:39])=[CH:34][CH:33]=2)[CH:3]=1>CCO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:16]=[CH:15][C:14]([N:17]=[CH:18][N:19]3[CH2:24][CH2:23][CH:22]([C:25]([OH:27])=[O:26])[CH2:21][CH2:20]3)=[CH:13][CH:12]=2)=[O:10])=[C:4]([C:30](=[O:40])[NH:31][C:32]2[CH:37]=[CH:36][C:35]([C:38]#[CH:39])=[CH:34][CH:33]=2)[CH:3]=1

Participants

3

Reactant 1

HCID 86587597HCID 86587597, compound

Product 1

HCID 86587596HCID 86587596, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl 1-{[4-(N-{4-chloro-2-[N-(4-ethynylphenyl)carbamoyl]phenyl}carbamoyl)-phenyl]iminomethyl}piperidine-4-carboxylate in EtOH was added 1N aq. LIOH (1 mL). The mixture was stirred for 3 hours, concentrated and purified by RP-HPLC to give the titled compound. MS found for C29H25ClN4O4 (M+1)+: 529.1.

Workup

  1. concentrationconcentrated
  2. custompurified by RP-HPLC

Sources & evidence

ORD record
ord-ff08c907191a4dfeadab80b1645624bf
Source dataset
uspto-grants-2007_12
Patent number
US07312235B2

Reaction notes

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