참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Amino-4-hydroxybenzothiazole | HCID 24057 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | (Diethoxyphosphoryl)methyl trifluoromethanesulfonate | HCID 11833487 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Amino-4-diethylphosphonomethyloxybenzothiazole | HCID 54277848 | — |
반응 단계
A mixture of 2-amino-4-hydroxybenzothiazole (1 mmole) and NaH (1.3 mmole) in DMF (5 L) was stirred at 0° C. for 10 min, and then treated with diethylphosphonomethyl trifluoromethylsulfonate (1.2 mmole). After being stirred at room temperature for 8 h, the reaction was subjected to extraction and chromatography to give 2-amino-4-diethylphosphonomethyloxybenzothiazole as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07312219B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_12 |
|---|
| ORD ID | ord-e00f547c64814cb39b27f09bdc7eda2b |
|---|
| 출처 메모 | uspto-grants-2007_12 |
|---|
