反应详情

Heat 1-(3-bromo-2-fluoro-phenyl)-4-dimethylamino-cyclohexanol (preparation 6, 2.04 g, 6.45 mmol) and p-TsOH monohydrate (3.07 g, 16 mmol) in toluene (50 mL) at reflux for 2 hr. Partition the reaction mixture between saturated aqueous NaCl and ethyl acetate, dry the organic phase with anhydrous sodium sulfate, evaporate the solvent, and purify the residue by chromatography on a silica gel column (DCM: 2M NH3 in MeOH, gradient) to give the title product (1.70 g): MS (ES): m/z=300 (M+H)+ and 298 (M−H)−. 1HNMR (CDCl3): δ 7.39 (m, 1H), 7.14 (m, 1H), 6.94 (m, 1H), 5.88 (m, 1H), 2.60-2.38 (m, 4H), 2.35 (s, 6H), 2.20 (m, 1H), 2.08 (m, 1H), 1.56 (m, 1H).

1. temperatureat reflux for 2 hr
2. customPartition the reaction mixture between saturated aqueous NaCl and ethyl acetate
3. dry with materialdry the organic phase with anhydrous sodium sulfate
4. customevaporate the solvent
5. custompurify the residue by chromatography on a silica gel column (DCM: 2M NH3 in MeOH, gradient)