2,4,6-Trifluorobenzoyl chloride → HCID 69350718, compound

Participants

Reaction Steps

Using a method similar to example 1, using 2,4,6-trifluorobenzoyl chloride (127 mg, 0.655 mmol) and 3-(4-dimethylamino-cyclohex-1-enyl)-phenylamine (preparation 2, 118 mg, 0.545 mmol) provides the title compound (free base, 180 mg, 88%). Free base: MS (ES): m/z=375.2 (M+H)+; 1H NMR (CDCl3): δ 7.78 (s, br, 1H), 7.67 (s, 1H), 7.48 (d, 1H), 7.32 (t, 1H), 7.22 (d, 1H), 6.78 (m, 2H), 6.12 (m, 1H), 2.50 (m, 4H), 2.37 (s, 6H), 2.15 (m, 2H), 1.57 (m, 1H). Hydrochloride salt: Anal. cal'd for C21H21F3N2O.HCl.H2O: C, 58.81; H, 5.64; N, 6.53. Found: C, 58.95; H, 5.30; N, 6.55.

Provenance & Evidence