3-Chloro-2,6-difluorobenzoyl chloride → HCID 69350631, compound

Participants

Reaction Steps

Using a method similar to example 1, using 3-chloro-2,6-difluorobenzoyl chloride (142 mg, 0.67 mmol) and 3-(4-dimethylamino-cyclohex-1-enyl)-phenylamine (preparation 2, 121 mg, 0.56 mmol) provides the title compound (free base 166 mg, 76%). Free base: MS (ES): m/z=391.2 (M+H)+; 1H NMR (CDCl3): δ 7.79 (s, br, 1H), 7.68 (br, 1H), 7.49 (m, 2H), 7.34 (t, 1H), 7.22 (d, 1H), 7.00 (dt, 1H), 6.12 (m, 1H), 2.46 (m, 4H), 2.38 (s, 6H), 2.15 (m, 2H), 1.59 (m, 1H). Hydrochloride salt: Anal. cal'd for C21H21ClF2N2O.HCl 0.25H2O: C, 58.41; H, 5.25; N, 6.49. Found: C, 58.65; H, 5.16; N, 6.51.

Provenance & Evidence