2-Chloro-6-fluorobenzoyl chloride → HCID 69351422, compound

Participants

Reaction Steps

Using a method similar to example 1, using 2-chloro-6-fluorobenzoyl chloride (132 mg, 0.69 mmol) and 3-(4-dimethylamino-cyclohex-1-enyl)-phenylamine (preparation 2, 124 mg, 0.57 mmol) provides the title compound (free base 208 mg, 98%). Free base: MS (ES): m/z=373.2 (M+H)+; 1H NMR (CDCl3): δ 7.68 (m, 2H), 7.52 (d, 1H), 7.36 (m, 2H), 7.25 (m, 1H), 7.23 (t, 1H), 7.10 (m, 1H), 6.12 (m, 1H), 2.50 (m, 4H), 2.36 (s, 6H), 2.15 (m, 2H), 1.58 (m, 1H). Hydrochloride salt: Anal. cal'd for C21H22ClFN2O.HCl 0.6H2O: C, 60.03; H, 5.81; N, 6.67. Found: C, 59.75; H, 5.31; N, 6.55.

Provenance & Evidence