2-Chloro-4-fluorobenzoyl chloride → HCID 69351039, compound

Participants

Reaction Steps

Using a method similar to example 1, using 2-chloro-4-fluorobenzoyl chloride (128 mg, 0.66 mmol) and 3-(4-dimethylamino-cyclohex-1-enyl)-phenylamine (preparation 2, 119 mg, 0.55 mmol) provides the title compound (free base 187 mg, 91%). Free base: MS (ES): m/z=373.2 (M+H)+; 1H NMR (CDCl3): δ 8.08 (s, br, 1H), 7.77 (m, 1H), 7.68 (s, br, 1H), 7.52 (d, 1H), 7.32 (t, 1H), 7.19 (m, 2H), 7.09 (m, 1H), 6.11 (m, 1H), 2.51 (m, 4H), 2.36 (s, 6H), 2.14 (m, 2H), 1.57 (m, 1H). Hydrochloride salt: Anal. cal'd for C21H22ClFN2O.HCl.0.5H2O: C, 60.29; H, 5.78; N, 6.70. Found: C, 60.17; H, 5.45; N, 6.65.

Provenance & Evidence