4-Fluorobenzoyl chloride → HCID 11337818, compound

Participants

Reaction Steps

Use a method similar to example 1, use 3-(4-dimethylamino-cyclohex-1-enyl)-phenylamine (enantiomer 2, preparation 3, 169 mg, 0.78 mmol) and 4-fluorobenzoyl chloride (149 mg, 0.94 mmol) to provide 89 mg (34%) of the free base of the title compound: MS (ES): m/z=339.2 (M+H)+; 1H NMR (CDCl3): δ 7.91 (m, 3H), 7.69 (br, 1H), 7.50 (d, 1H), 7.33 (t, 1H), 7.18 (m, 3H), 6.13 (m, 1H), 2.51 (m, 4H), 2.37 (s, 6H), 2.13 (m, 2H), 1.57 (m, 1H). Hydrochloride salt: Anal. cal'd for C21H23FN2O.HCl.0.5H2O: C, 65.70; H, 6.56; N, 7.30. Found: C, 65.30; H, 6.16; N, 7.21.

Provenance & Evidence