2,4,6-Trifluorobenzoyl chloride → HCID 69350718, compound

Participants

Reaction Steps

Using a method similar to example 1, using 2,4,6-trifluorobenzoyl chloride (105 mg, 0.54 mmol) and chiral 3-(4-dimethylamino-cyclohex-1-enyl)-phenylamine (enantiomer 2, preparation 3, 97 mg, 0.45 mmol) provides of the free base of the title compound (free base 142 mg, 85%): Free base: MS (ES): m/z=375.2 (M+H)+; 1H NMR (CDCl3): δ 7.80 (s, br, 1H), 7.66 (t, 1H), 7.48 (d, 1H), 7.32 (t, 1H), 7.21 (dt, 1H), 6.78 (m 2H), 6.12 (m, 1H), 2.54 (m, 4H), 2.37 (s, 6H), 2.14 (m, 2H), 1.57 (m, 1H). Hydrochloride salt: Anal. cal'd for C21H21F3N2O.HCl.1.2H2O: C, 58.32; H, 5.69; N, 6.48. Found: C, 58.21; H, 5.03; N, 6.39.

Provenance & Evidence