2,4,6-Trifluorobenzoyl chloride → HCID 69350874, compound

Participants

Reaction Steps

Using a method similar to example 10, using 2,4,6-trifluoro-benzoyl chloride and 3-(4-dimethylamino-cyclohex-1-enyl)-5-fluoro-phenylamine (isomer 5A, preparation 5) provides the title compound: Free base MS (ES) m/z=393 (M+H)+; 1H NMR of free base (CDCl3): δ 7.68 (s, 1H), 7.42 (d, 1H, J=10 Hz), 7.28 (s, 1H), 6.91 (dd, 1H, J=10 Hz, J=2 Hz), 6.77 (dd, 2H, J=10 Hz, J=10 Hz), 6.11 (bs, 1H), 2.43 (m, 4H), 2.35 (s, 6H), 2.16 (m, 2H), 1.58 (m, 1H).

Provenance & Evidence