2-Chloro-6-fluorobenzoyl chloride → HCID 69350870、化合物

関与物質

反応手順

Using a method similar to example 1, using 2-chloro-6-fluoro-benzoyl chloride (116 mg, 0.60 mmol) and 6-(4-dimethylamino-cyclohex-1-enyl)-pyridin-2-ylamine, isomer 1 (preparation 10, 100 mg, 0.46 mmol) provides the free amine of the title compound as a colorless oil (78 mg, 45%): MS (ES): m/z=374.1 (M+H)+; 1H NMR (CDCl3): δ 9.03 (s, br, 1H), 8.26 (d, 1H), 7.73 (t, 1H), 7.30 (m, 1H), 7.19 (d, 1H), 7.09 (d, 1H), 6.98 (dt, 1H), 6.62 (m, 1H), 2.58 (m, 1H), 2.38 (m, 3H), 2.34 (s, 6H), 2.15 (m, 2H), 1.53 (m, 1H). Using a salt formation method similar to that in example 1 provides the di-hydrochloride salt.

情報源と証拠