反应详情

Using a method similar to example 1, using 2,4-difluoro-benzoyl chloride (106 mg, 0.60 mmol) and 6-(4-dimethylamino-cyclohex-1-enyl)-pyridin-2-ylamine (preparation 10, 100 mg, 0.46 mmol) provides the free amine of the title compound as a colorless oil (59 mg, 36%): MS (ES): m/z=358.2 (M+H)+; 1H NMR (CDCl3): δ 8.94 (d, 1H), 8.21 (m, 2H), 7.72 (t, 1H), 7.19 (d, 1H), 7.04 (m, 2H), 6.71 (m, 1H), 2.78 (m, 1H), 2.49 (m, 3H), 2.38 (s, 6H), 2.17 (m, 2H), 1.59 (m, 1H). Using a salt formation method similar to that in example 1 gives the dihydrochloride salt: Di-hydrochloride salt: Anal cal'd for C20H21F2N3O.2HCl: C, 55.82; H, 5.39; N, 9.76. Found: C, 56.15; H, 5.49; N, 9.73.