2,4-Difluorobenzoyl chloride → HCID 69351527, compound

Participants

Reaction Steps

Using a method similar to example 24, using 2,4-difluoro-benzoyl chloride (141 mg, 0.80 mmol) and 6-(4-dimethylamino-cyclohex-1-enyl)-pyridin-2-ylamine, isomer 2 (preparation 11, 145 mg, 0.67 mmol) provides the free amine of the title compound as a colorless oil (225 mg, 94%): MS (ES): m/z=358.1 (M+H)+; 1H NMR (CDCl3): δ 8.94 (d, 1H), 8.21 (m, 2H), 7.72 (t, 1H), 7.19 (d, 1H), 7.04 (m, 2H), 6.71 (m, 1H), 2.78 (m, 1H), 2.49 (m, 3H), 2.38 (s, 6H), 2.17 (m, 2H), 1.59 (m, 1H). Using a salt formation method similar to that in example 1 gives the dihydrochloride salt.

Provenance & Evidence