2-Bromobenzoyl chloride → HCID 69350334, compound

Participants

Reaction Steps

Using a method similar to example 1, using 2-bromobenzoyl chloride (151 mg, 0.69 mmol) and 6-(4-dimethylamino-cyclohex-1-enyl)-pyridin-2-ylamine, isomer 2 (preparation 11, 100 mg, 0.46 mmol) provides the free amine of the title compound as an oil (63 mg, 34%): MS (ES): m/z=400 (M+H)+, 403 (M+3); 1H NMR (CD3OD): δ 8.30 (t, 1H), 7.69 (d, 2H), 7.67 (d, 1H), 7.49 (m, 3H), 6.78 (m, 1H), 3.55 (m, 1H), 2.87 (s, 6H), 2.73 (m, 4H), 2.37 (m, 1H), 1.87 (m, 1H). Using a salt formation method similar to that in example 1 gives the dihydrochloride salt.

Provenance & Evidence