2,4,6-Trifluorobenzoyl chloride → N-(6-(4-Dimethylamino-cyclohex-1-enyl)-pyridin-2-yl)-2,4,6-trifluoro-benzamide dihydrochloride salt

関与物質

反応手順

Using a method similar to example 1, using 2,4,6-trifluoro-benzoyl chloride (134 mg, 0.69 mmol) and 6-(4-dimethylamino-cyclohex-1-enyl)-pyridin-2-ylamine, isomer 2 (preparation 11, 100 mg, 0.46 mmol) provides the free amine of the title compound as an oil (80 mg, 46%): MS (ES): m/z=376.2 (M+H)+; 1H NMR (CD3OD): δ 8.25 (t, 1H), 7.67 (d, 1H), 7.74 (d, 1H), 7.12 (t, 2H), 6.81 (m, 1H), 3.62 (m, 1H), 2.96 (s, 6H), 2.73 (m, 4H), 2.45 (m, 1H), 1.95 (m, 1H). Using a salt formation method similar to that in example 1 gives the dihydrochloride salt.

情報源と証拠