Methanol → Methyl (benzylthio)acetate

HRID 970780Notes

Reaction equation

HRID 970780 reaction equation
[CH2:1]([S:8][CH2:9][C:10]([OH:12])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:13]O>>[CH2:1]([S:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 668972-((Phenylmethyl)thio)acetic acid

Product 1

HCID 562502Methyl (benzylthio)acetate

Procedure

S-benzylthioglycolic acid (12.0 g) was dissolved in 250 mL of methanol and sparged with hydrogen chloride gas at room temperature for 20 minutes. The solvent was then removed under vacuum. Methyl S-benzylthioglycolate obtained was used in the next step without further purification.

Workup

  1. customsparged with hydrogen chloride gas at room temperature for 20 minutes
  2. customThe solvent was then removed under vacuum

Sources & evidence

ORD record
ord-526fc892d62a4a9d81ecb4774b6984bb
Source dataset
uspto-grants-2007_12
Patent number
US07312247B2

Reaction notes

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