HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 970796Generated: October 25, 2026
Triethylamine → (R)-2-(5-Thiophen-3-yl-benzofuran-2-ylmethoxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester
https://huagongshe.com/reaction/970796
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl (R)-(+)-2-isocyanato-3-phenylpropionate | HCID 6558897 | — |
| Reactant | HCID 12990912 | HCID 12990912 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (R)-2-(5-Thiophen-3-yl-benzofuran-2-ylmethoxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester | HCID 12990913 | 47.6% |
Reaction Steps
A mixture of 2-hydroxymethyl-5-thiophen-3-yl-benzofuran 22 (0.31 g, 1.35 mmole), (R)-2-isocyanato-3-phenyl-propionic acid methyl ester 5 (0.33 g, 1.6 mmole), triethylamine (0.43 ml), and THF (25 ml) was heated to 50° C. under a nitrogen atmosphere for 14 hrs. The solvent was removed under reduced pressure and the residue was purified by chromatography giving about 0.28 g of (R)-2-(5-thiophen-3-yl-benzofuran-2-ylmethoxycarbonylamino)-3-phenylpropionic acid methyl ester 23, mp. 105-106° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07312230B2 |
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| Source dataset | uspto-grants-2007_12 |
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| ORD ID | ord-b6a9f8dd59554d8294bf2cebea7e80e4 |
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| Source note | uspto-grants-2007_12 |
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