反应详情

5-methyl-2-phenylbenzoxazole 55 (1.23 g, 5.8 mmol) and NBS (1.17 g, 6.5 mmol) were dissolved in carbon tetrachloride (20 ml). The mixture was evacuated and flushed with argon. AIBN (ca. 5 mg) was added and the mixture heated at reflux and irradiated with a sun lamp for 3 hrs. The solvent was evaporated under reduced pressure and the residue purified by chromatography to yield 1.18 g of 5-bromomethyl-2-phenylbenzoxazole 56.

1. customThe mixture was evacuated
2. customflushed with argon
3. additionAIBN (ca. 5 mg) was added
4. temperaturethe mixture heated
5. temperatureat reflux
6. customirradiated with a sun lamp for 3 hrs
7. customThe solvent was evaporated under reduced pressure
8. customthe residue purified by chromatography