Toluene → HCID 12990928, compound

Participants

Reaction Steps

A mixture of 2-(phenylbenzoxazol-5-yl)methanol 58 (215 mg, 0.95 mmol), (R)-2-isocyanato-3-phenylpropionic acid methyl ester 5(196 mg, 0.95 mmol), DMAP (12 mg, 0.095 mmol) and toluene (12 ml) was heated at reflux under an atmosphere of N2 for 3 hrs. The solvent was removed under reduced pressure and the residue purified by chromatography to yield 381 mg of (R)-2-(2-Phenylbenzoxazol-5-ylmethoxycarbonylamino)-3-phenylpropionic acid methyl ester 59.

Provenance & Evidence