HCID 22601342, compound → HCID 22601393, compound

Participants

Reaction Steps

3-Hydroxymethyl-N-pyridin-2-ylmethyl-benzenesulfonamide (crude from previous step, 2.87 mmol) and MnO2 (2.9 g, 28.7 mmol) in methanol (0.5 mL) and CH2Cl2 (15 mL) were reacted at 50° C. under N2 overnight. The mixture was concentrated and purified by chromatography on silica gel (50% ethyl acetate and CH2Cl2) to afford the title compound (600 mg, 79% over two steps) as a white foam.

Provenance & Evidence