Acetic Acid → HCID 68899844, compound

Participants

Reaction Steps

Using general procedure B: Reaction of 1-(2-Trimethylsilanyl-ethoxymethyl)-1H-benzimidazole-2-carbaldehyde (192 mg, 0.70 mmol), N-Pyridin-2-ylmethyl-3-[(5,6,7,8-tetrahydro-quinolin-8-ylamino)-methyl]-benzenesulfonamide (284 mg, 0.70 mmol), acetic acid (0.2 mL) and sodium triacetoxyborohydride (442 mg, 2.08 mmol) in THF (7 mL) at room temperature under N2 for 40 min., followed by purification of the crude material by chromatography on silica gel (1:1:98 CH3OH—NH3H2O—CH2Cl2,), afforded the title compound (177 mg, 38%) as a white foam.

Provenance & Evidence