HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 3-(Phenylsulfamoyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Benzoic acid, 3-(chlorosulfonyl)- | HCID 77641 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(Phenylsulfamoyl)benzoic acid | HCID 759339 | 100.8% |
Reaction Steps
3-Chlorosulfonyl-benzoic acid (300 mg, 1.36 mmol), and aniline (0.30 mL, 3.29 mmol) were stirred at room temperature in anhydrous CH2Cl2 (10 mL) overnight under N2. The reaction mixture was concentrated in vacuo. Purification of the residue on IR-120 ion exchange resin column (eluted with methanol) afforded the title compound (380 mg, 100%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07312234B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-15936342bb054069a8bc3805e5cbe2f5 |
| Source note | uspto-grants-2007_12 |